环境科学
环境科学
水体污染
大气污染
土壤污染
应用前景：无论是大气污染、水污染还是土壤污染，最终都将影响依赖环境生存的生物体，研究这些环境污染是怎样影响到生物体，代谢组学研究会将提供一个全新的角度。
海洋污染对贻贝代谢的影响
研究背景
研究目的
实验设计
研究结果——环境科学新方法
1Priolo贻贝消化腺表现出组织学病变，如：憩室形态改变、明显的溶血性渗透。这些或许会损伤其代谢活动；2Priolo贻贝中氨基酸水平明显上升。据报道，游离氨基酸及它们的分解产物可以平衡细胞渗透压，Priolo贻贝中氨基酸含量的明显上升与有毒物质对细胞渗透压造成干扰有直接关系；3能量代谢的改变亦被观察到，有氧呼吸被抑制导致乳酸上升；4Priolo贻贝体内乙酰乙酸的含量升高。乙酰乙酸是一种重要的酮体，是脂肪氧化的终产物。乙酰乙酸的上升和脂质代谢的改变有关，而苯丙氨酸、赖氨酸、亮氨酸、异亮氨酸和酪氨酸在一定代谢条件下可以转化为乙酰乙酸。乙酰乙酸可以反应生成琥珀酸；
5增加的琥珀酸和延胡索酸通过柠檬酸循环可以转为为草酸乙酸盐，它是氨基酸、嘌吟和嘧啶的前体，这个结果与含氮碱基的增加相一致；6Priolo贻贝中谷氨酸含量的降低与糖酵解代谢相关；7Priolo贻贝中腺嘌吟的升高与精氨酸的出现有关。精氨酸是磷酸精氨酸和ADP反应的终产物，而磷酸精氨酸是无脊椎动物中ATP再生中主要的高能磷酸肌酸，这个变化与ATP代谢的改变相吻合。
通过代谢组信息可以观察到污染对生物体造成的影响，表明在生态毒理方面，代谢组学是可以评估环境对生物体健康状况的影响。原文索引：
Metabolomic investigation of Mytilus galloprovincialis (Lamarck 1819) caged in aquatic environments, Ecotoxicology of Environmental Safety, 2012, 84: 139-146
环境科学领域2015年发表的文献
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